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In vitro and in vivo antidermatophyte activities of NND-502, a novel optically active imidazole antimycotic agent.

Authors
  • Niwano, Y
  • Kuzuhara, N
  • Kodama, H
  • Yoshida, M
  • Miyazaki, T
  • Yamaguchi, H
Type
Published Article
Journal
Antimicrobial agents and chemotherapy
Publication Date
Apr 01, 1998
Volume
42
Issue
4
Pages
967–970
Identifiers
PMID: 9559824
Source
Medline
License
Unknown

Abstract

In vitro and in vivo antidermatophyte activities of NND-502, a new imidazole antimycotic agent, were compared with those of two existing antifungal agents, lanoconazole and terbinafine. NND-502 exhibited strong in vitro antifungal activity against Trichophyton spp.; its MIC was 1 to 4 times lower than that of lanoconazole or terbinafine. In an in vivo study with a guinea pig model of tinea pedis, 7-day topical treatment with a 0.5% solution of NND-502 (dissolved in polyethylene glycol 400) was more effective than that with a 0.5% solution of either lanoconazole or terbinafine for eradicating fungi from the infected feet. When the duration of treatment was shortened to 3 days, a topical 1% solution of NND-502 achieved a complete mycological cure, while topical 1% solutions of lanoconazole and terbinafine did not.

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