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In vitro study of antiadipogenic profile of latanoprost, travoprost, bimatoprost, and tafluprost in human orbital preadiopocytes.

Authors
  • Choi, Hee Young
  • Lee, Ji Eun
  • Lee, Ji Woong
  • Park, Hyun Jun
  • Lee, Ji Eun
  • Jung, Jae Ho
Type
Published Article
Journal
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
Publication Date
Apr 01, 2012
Volume
28
Issue
2
Pages
146–152
Identifiers
DOI: 10.1089/jop.2011.0160
PMID: 22107041
Source
Medline
License
Unknown

Abstract

Latanoprost, travoprost, bimatoprost, and tafluprost inhibited human preadipocyte differentiation and intracellular lipid accumulation. Morphologic and metabolic changes in orbital adipocytes caused by PGF2α analogs are a possible pathophysiologic explanation of superior eyelid deepening in patients with glaucoma.

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