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In vitro studies of elastin-fibrin biomaterial degradation: preservative effects of protease inhibitors and antibiotics.

Authors
  • Collet, D1
  • Lefebvre, F
  • Quentin, C
  • Rabaud, M
  • 1 INSERM, Unité 306, Université de Bordeaux II, France. , (France)
Type
Published Article
Journal
Biomaterials
Publisher
Elsevier
Publication Date
Oct 01, 1991
Volume
12
Issue
8
Pages
763–766
Identifiers
PMID: 1724734
Source
Medline
License
Unknown

Abstract

The degradability of a new elastin-fibrin material was tested in vitro versus human pancreatic elastase (HPE) and plasmin (PL) activities. It is shown that aprotinine Iniprol, a well-known protease inhibitor and Eglin C, a new potent inhibitor of HPE, especially when used in synergy, efficiently protected the material. A small amount of specific antibiotics was incorporated into the material. The two products will allow the material to be used in digestive surgery with improved safety.

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