In vitro studies of elastin-fibrin biomaterial degradation: preservative effects of protease inhibitors and antibiotics.
INSERM, Unité 306, Université de Bordeaux II, France.
- Published Article
- Publication Date
Oct 01, 1991
The degradability of a new elastin-fibrin material was tested in vitro versus human pancreatic elastase (HPE) and plasmin (PL) activities. It is shown that aprotinine Iniprol, a well-known protease inhibitor and Eglin C, a new potent inhibitor of HPE, especially when used in synergy, efficiently protected the material. A small amount of specific antibiotics was incorporated into the material. The two products will allow the material to be used in digestive surgery with improved safety.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/1724734