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In vitro studies on biocompatibility of hyaluronic acid esters.

Authors
  • Cortivo, R1
  • Brun, P
  • Rastrelli, A
  • Abatangelo, G
  • 1 Institute of Histology, University of Padova, Italy. , (Italy)
Type
Published Article
Journal
Biomaterials
Publisher
Elsevier
Publication Date
Oct 01, 1991
Volume
12
Issue
8
Pages
727–730
Identifiers
PMID: 1799648
Source
Medline
License
Unknown

Abstract

The biocompatibility of semisynthetic polymers formed from hyaluronic acid esters has been studied using fibroblast cultures. The polymers, added to the culture medium, used either in powdered form or as thin membranes, behave as inert materials. The cells used in the experiments grow normally in the culture dishes. With regard to adhesiveness the cells were not able to spread on the biomembranes and tended to form isolated clusters of round cells. Human fibronectin, placental collagen (type I-IV) and fibrin could be stratified on biomembranes. When these molecules reacted with the biomaterial the film became suitable for fibroblasts spreading and growth.

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