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In vitro studies of antiglaucomatous prostaglandin analogues: travoprost with and without benzalkonium chloride and preserved latanoprost.

Authors
  • Baudouin, Christophe
  • Riancho, Luisa
  • Warnet, Jean-Michel
  • Brignole, Françoise
Type
Published Article
Journal
Investigative Ophthalmology & Visual Science
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Publication Date
Sep 01, 2007
Volume
48
Issue
9
Pages
4123–4128
Identifiers
PMID: 17724196
Source
Medline
License
Unknown

Abstract

Latanoprost with BAK, travoprost with BAK, and BAK alone have significant cytotoxic effects on human conjunctiva-derived cells and are associated with apoptosis. These effects likely result from BAK used as a preservative. IOP-lowering agents with alternative preservatives instead of BAK will most likely have fewer ocular surface adverse effects than agents containing BAK.

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