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In vitro sensitivity of clonogenic cells in resisting and relapsing patients with acute myelogenous leukaemia.

Authors
  • Marie, J P
  • Zittoun, R
  • Thevenin, D
Type
Published Article
Journal
British journal of cancer
Publication Date
Nov 01, 1988
Volume
58
Issue
5
Pages
570–574
Identifiers
PMID: 3219266
Source
Medline
License
Unknown

Abstract

The evolution of in vitro bone marrow clonogenic leukaemic cells (CFU-L) drug sensitivity was studied in 23 patients with acute myeloid leukaemia treated with anthracycline and cytosine arbinoside (ara-C). In 12 patients tested before and after first induction treatment failure (interval: 6 +/- 4 weeks), the sensitivity remained stable for daunorubicin and showed little variation for ara-C. Among eleven patients tested before treatment and at first relapse (interval: 13 +/- 7 months), in vitro CFU-L sensitivity revealed no correlation between the two measurements, and a trend in decreased sensitivity to daunorubicin and ara-C. These findings suggest that induction failures could be related to factors other than simple selection of a resistant CFU-L subclone.

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