Affordable Access

[In vitro metabolic studies of the novel anti-anxietic drug AF-5 and its metabolites in human liver microsome incubation system].

Authors
  • Li, N
  • Zhang, J L
  • Zhou, T H
Type
Published Article
Journal
Yao xue xue bao = Acta pharmaceutica Sinica
Publication Date
Jul 01, 2001
Volume
36
Issue
7
Pages
528–531
Identifiers
PMID: 12585086
Source
Medline
License
Unknown

Abstract

In human liver microsome incubation system AF-5 was completely metabolized in 100 min to the hydroxy derivative I and carbonyl derivative II, with hydroxymetabolite as the major metabolite. Metabolite I was further transformed to metabolite II, which was not metabolized any further by the human liver microsomes.

Report this publication

Statistics

Seen <100 times