[In vitro metabolic studies of the novel anti-anxietic drug AF-5 and its metabolites in human liver microsome incubation system].
- Published Article
Yao xue xue bao = Acta pharmaceutica Sinica
- Publication Date
Jul 01, 2001
In human liver microsome incubation system AF-5 was completely metabolized in 100 min to the hydroxy derivative I and carbonyl derivative II, with hydroxymetabolite as the major metabolite. Metabolite I was further transformed to metabolite II, which was not metabolized any further by the human liver microsomes.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/12585086