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In vitro measurement of platelet adhesion to intact endothelial cells under low shear conditions.

Authors
  • Ogawa, Yuki1
  • Nakahara, Takuma1
  • Nishida, Yuma1
  • Kobayashi, Chihiro2
  • Hirata, Takamichi2
  • Nagano, Hideaki1
  • Shiratori, Suguru1
  • Shimano, Kenjiro1
  • 1 Department of Mechanical Systems Engineering, Tokyo City University, Tokyo, Japan. , (Japan)
  • 2 Department of Medical Engineering, Tokyo City University, Tokyo, Japan. , (Japan)
Type
Published Article
Journal
Biorheology
Publication Date
Jan 01, 2018
Volume
54
Issue
2-4
Pages
51–65
Identifiers
DOI: 10.3233/BIR-17139
PMID: 29355112
Source
Medline
Keywords
License
Unknown

Abstract

The number of adherent platelets is determined by a balance between the shear and the degree of stimulation by the agonist. At an ADP concentration of 1 µM, a limit to the shear rate at which platelets can adhere to intact endothelial cells is considered to be slightly higher than 16.8 s-1.

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