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In vitro generation of cytolytic T cells against human melanoma cells overexpressing HDM2.

Authors
  • Soruri, Afsaneh
  • Fayyazi, Afshin
  • Gangl, Stefanie
  • Griesinger, Christian
  • Albrecht, Christian A
  • Schlott, Thilo
Type
Published Article
Journal
Anticancer research
Publication Date
Jan 01, 2004
Volume
24
Issue
4
Pages
2141–2151
Identifiers
PMID: 15330154
Source
Medline
License
Unknown

Abstract

These data suggest that HDM2441 may be exploited for broad-spectrum DC-based trials against metastatic melanomas overexpressing HDM2, and point out that the efficacy of such immunotherapeutical approaches may be limited via T cell apoptosis.

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