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In Vitro Evidences of Heparin’s Effects on Embryo Implantation and Trophoblast Development

Authors
  • Tersigni, Chiara1
  • Marana, Riccardo2
  • Santamarìa, Amparo1
  • Castellani, Roberta1
  • Scambia, Giovanni1
  • Di Simone, Nicoletta1
  • 1 Università Cattolica del Sacro Cuore, Largo Gemelli, Rome, 8,00168, Italy , Rome (Italy)
  • 2 Universitat Autónoma de Barcelona, Barcelona, Spain , Barcelona (Spain)
Type
Published Article
Journal
Reproductive Sciences
Publisher
SAGE Publications
Publication Date
May 01, 2012
Volume
19
Issue
5
Pages
454–462
Identifiers
DOI: 10.1177/1933719111430994
Source
Springer Nature
Keywords
License
Yellow

Abstract

Heparin seems to be effective in ameliorating pregnancy outcome in thrombophilic women with previous recurrent pregnancy loss, preeclampsia, intrauterine growth restriction and sudden fetal death. A prophylactic effect of heparin treatment has also been proposed in terms of prevention of adverse pregnancy outcomes recurrence in women with history of recurrent miscarriage, severe preeclampsia, placental abruption, low neonatal birth weight and intrauterine fetal death not related to thrombophilia, although literature in this field is quite controversial. The molecular mechanisms by which heparin might exert its potential therapeutic effects in human reproduction are still not fully understood. In this article we review the current knowledge in this research field, focusing on in vitro evidences of heparin’s mechanisms of action in the processes of embryo implantation and trophoblast invasion.

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