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In Vitro Evaluation of Drug Content in and Drug Release Kinetics from Stents with Different Types of Polymer Coating

Authors
  • Prostyakova, A. I.1
  • Zybin, D. I.2
  • Kapustin, D. V.1
  • 1 Russian Academy of Sciences, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, 16/10 Miklukho-Maklaya St., Moscow, 117997, Russian Federation , Moscow (Russia)
  • 2 Moscow Technological University, Institute of Fine Chemical Technologies, 86 Prosp. Vernadskogo, Moscow, 119571, Russia , Moscow (Russia)
Type
Published Article
Journal
Pharmaceutical Chemistry Journal
Publisher
Springer US
Publication Date
Mar 11, 2019
Volume
52
Issue
12
Pages
1011–1015
Identifiers
DOI: 10.1007/s11094-019-01943-y
Source
Springer Nature
Keywords
License
Yellow

Abstract

Drug elution profiles must be studied in vitro to optimize a polymer-drug formulation during development of drug-eluting stents (DESs). Results from HPLC assays of drug contents and elution kinetics from a biodegradable sirolimus coating and a stable zotarolimus coating on coronary DESs are presented. Drug contents were assessed for crimped stents on the delivery system and expanded stents. The drug coating morphology and elution kinetics were demonstrated to be associated. Significant coating morphological defects were shown to cause deviations in the drug elution profile.

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