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In vitro effects of albendazole and its metabolites on the cell proliferation kinetics and micronuclei frequency of stimulated human lymphocytes.

Authors
Type
Published Article
Journal
Archives of Medical Research
0188-4409
Publisher
Elsevier
Publication Date
Volume
32
Issue
2
Pages
119–122
Identifiers
PMID: 11343808
Source
Medline
License
Unknown

Abstract

The formation of micronuclei may ultimately result in aneuploidy induction, an effect that could have severe consequences in humans. However, the doses of ABZ and SOABZ at which these effects were observed are several orders of magnitude higher than those found in the plasma of treated individuals. Because there are other mechanisms by which aneuploidy can be induced at even lower doses than micronuclei, i.e., chromosome nondisjunction, it is necessary to evaluate this effect in exposed individuals.

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