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In vitro effect of advanced glycation end-products on human polymorphonuclear superoxide production.

Authors
  • Bernheim, J
  • Rashid, G
  • Gavrieli, R
  • Korzets, Z
  • Wolach, B
Type
Published Article
Journal
European journal of clinical investigation
Publication Date
Dec 01, 2001
Volume
31
Issue
12
Pages
1064–1069
Identifiers
PMID: 11903493
Source
Medline
License
Unknown

Abstract

Advanced glycation end-products depress superoxide production by stimulated polymorphonuclear leukocytes. As superoxide plays an essential role in bactericidal activity, this polymorphonuclear leukocyte dysfunction may be a contributory factor to the increased prevalence and severity of bacterial infection seen in diabetic patients.

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