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In vitro comparison of the effect of two factor XI (FXI) concentrates on thrombin generation in major FXI deficiency.

Authors
  • Pike, G N1, 2
  • Cumming, A M3
  • Hay, C R M1, 4
  • Sempasa, B3
  • Sutherland, M3
  • Thachil, J1
  • Burthem, J1, 2
  • Bolton-Maggs, P H B4, 5
  • 1 Department of Haematology, Manchester Royal Infirmary, Central Manchester University Hospital NHS Trust, Manchester, UK.
  • 2 Institute of Cancer Sciences, The University of Manchester, Manchester, UK.
  • 3 Haematology Molecular Diagnostics Centre, Manchester Royal Infirmary, Central Manchester University Hospital NHS Trust, Manchester, UK.
  • 4 The University of Manchester, Manchester, UK.
  • 5 SHOT office, Manchester Blood Centre, Plymouth Grove, Manchester, UK.
Type
Published Article
Journal
Haemophilia : the official journal of the World Federation of Hemophilia
Publication Date
May 2016
Volume
22
Issue
3
Pages
403–410
Identifiers
DOI: 10.1111/hae.12846
PMID: 26558335
Source
Medline
Keywords
License
Unknown

Abstract

Both FXI concentrates improve TG in vitro in major FXI deficiency but differ in dose response, and for both products, doses lower than previously recommended normalized TG in vitro. Comparison of in vitro spiked and ex vivo samples suggest that in vitro results could be used to estimate an expected in vivo response to FXI replacement.

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