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In vitro chondrogenesis in human chondrodysplasias.

Authors
  • Horton, W A
Type
Published Article
Journal
American journal of medical genetics
Publication Date
Jan 15, 1993
Volume
45
Issue
2
Pages
179–182
Identifiers
PMID: 8456799
Source
Medline
License
Unknown

Abstract

Bone morphogenesis depends on the sequential expression of multiple genes that first allow formation of mesenchymal anlagen, their replacement by cartilage models, and finally, the synthesis of new bone at growth plates. These processes require orchestration of synthesis of multiple collagens, proteoglycans and glycoproteins, the genes for many of which have been isolated and are being studied. Several genes carry mutations which are responsible for the chondrodysplasia phenotypes and can be studied at the gene level or by examining their expression in cultured chondrocytes.

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