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In vitro cell tests of pancreatic malignant tumor cells by photothermotherapy based on DMSO porous silicon colloids.

Authors
  • Hong, Chanseok
  • Lee, Chongmu
Type
Published Article
Journal
Lasers in Medical Science
Publisher
Springer-Verlag
Publication Date
Jan 01, 2014
Volume
29
Issue
1
Pages
221–223
Identifiers
DOI: 10.1007/s10103-013-1316-3
PMID: 23604846
Source
Medline
License
Unknown

Abstract

Dimethyl sulfoxide porous silicon (DMSO-PSi) colloid in which DMSO was used as a surfactant suitable for inhibiting the agglomeration of PSi nanoparticles was prepared for use in cancer photothermotherapy. The photothermal effect of the DMSO-PSi colloid was found to be high enough to destroy cancer cells (T = ∼52 °C). The mean particle size of the PSi nanoparticles in the DMSO-PSi colloid was 67 nm, which is low enough to flow through blood vessels without causing a blockage. The DMSO-PSi colloid in combination with an NIR laser resulted in a cell viability of 5.70%, which is a sufficiently high cytotoxic effect.

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