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In vitro assessment of antiretroviral drugs demonstrates potential for ototoxicity

Authors
  • Thein, Pru
  • Kalinec, Gilda M.
  • Park, Channy
  • Kalinec, Federico1, 2
  • 1 Department of Head and Neck Surgery
  • 2 David Geffen School of Medicine at UCLA
Type
Published Article
Journal
Hearing Research
Publisher
Elsevier BV
Publication Date
Jan 01, 2014
Accepted Date
Jan 20, 2014
Volume
310
Pages
27–35
Identifiers
DOI: 10.1016/j.heares.2014.01.005
Source
Elsevier
Keywords
License
Unknown

Abstract

•In vitro studies suggest that several common anti-HIV drugs are likely ototoxic.•Cocktails used in High-Activity Anti-Retroviral Therapy are toxic for HEI-OC1 cells.•Anti retrovirals-induced cell death was associated with caspase-independent mechanisms.

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