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The in vitro antiviral activity of an aliphatic nitro compound from Heteropteris aphrodisiaca.

Authors
  • Melo, Fernando L
  • Benati, Fabricio J
  • Roman, Walter Antonio Jr
  • de Mello, João Carlos Palazzo
  • Nozawa, Carlos
  • Linhares, Rosa Elisa Carvalho
Type
Published Article
Journal
Microbiological Research
Publisher
Elsevier
Publication Date
Jan 01, 2008
Volume
163
Issue
2
Pages
136–139
Identifiers
PMID: 16735108
Source
Medline
License
Unknown

Abstract

We investigated the antiviral activity of an aliphatic nitro compound (NC) isolated from Heteropteris aphrodisiaca O. Mach. (Malpighiaceae), a Brazilian medicinal plant. The NC was tested for its antiviral activity against poliovirus type 1 (PV-1) and bovine herpes virus type 1 (BHV-1) by plaque reduction assay in cell culture. The NC showed a moderate antiviral activity against PV-1 and BHV-1 in HEp-2 cells, and the 50% inhibitory concentration (IC50) were 22.01 microg/ml (selectivity index (SI)=2.83) and 21.10 microg/ml (SI=2.95), respectively. At the highest concentration of the drug (40 microg/ml) a reduction of approximately 80% in plaque assay was observed for both viruses. The treatment of cells or virus prior to infection did not inhibit the replication of virus strains.

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