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In vitro anti-Candida activity of certain new 3-(1H-imidazol-1-yl)propan-1-one oxime esters.

Authors
  • Attia, Mohamed I
  • Zakaria, Azza S
  • Almutairi, Maha S
  • Ghoneim, Soraya W
Type
Published Article
Journal
Molecules
Publisher
MDPI AG
Publication Date
Jan 01, 2013
Volume
18
Issue
10
Pages
12208–12221
Identifiers
DOI: 10.3390/molecules181012208
PMID: 24084023
Source
Medline
License
Unknown

Abstract

Anti-Candida activities of certain new oximes 4a-d and their respective aromatic esters 5a-l are reported. The tested compounds 4a-d and 5a-l exhibited better anti-Candida profiles than fluconazole. Compound 5j, namely (E)-3-(1H-imidazol-1-yl)-1-phenylpropan-1-one O-4-chlorobenzoyl oxime emerged as the most active congener, with a MIC value of 0.0054 µmol/mL being more potent than both fluconazole (MIC > 1.6325 µmol/mL) and miconazole (MIC value = 0.0188 µmol/mL) as a new anti-Candida albicans agent.

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