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In vitro activity of KRM-1648, either singly or in combination with ofloxacin, against Mycobacterium ulcerans.

Authors
  • Dhople, A M
Type
Published Article
Journal
International Journal of Antimicrobial Agents
Publisher
Elsevier
Publication Date
Jan 01, 2001
Volume
17
Issue
1
Pages
57–61
Identifiers
PMID: 11137650
Source
Medline
License
Unknown

Abstract

The antimicrobial effect of a benzoxazinorifamycin, KRM-1648, either alone or in combination with ofloxacin, was evaluated in vitro against two type strains and six clinical isolates of Mycobacterium ulcerans. Growth of M. ulcerans was measured by plate counts and the BACTEC radiometric method. The minimal inhibitory concentration as well as minimal bactericidal concentration of KRM-1648 against M. ulcerans was between 0.012 and 0.025 mg/l, while corresponding values for rifampicin and rifabutin were in the range of 0.1-0.8 mg/l and 0.1-0.4 mg/l respectively. When combined with ofloxacin, KRM-1648 exhibited strong synergistic activity while only additive effects were observed with the combination of rifampicin (or rifabutin) and ofloxacin. These results suggest that KRM-1648 has a great potential in the treatment of M. ulcerans infection.

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