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In vitro activity of an aqueous allicin extract and a novel allicin topical gel formulation against Lancefield group B streptococci.

Authors
  • Cutler, Ronald R
  • Odent, Michel
  • Hajj-Ahmad, Hussein
  • Maharjan, Sunil
  • Bennett, Norman J
  • Josling, Peter D
  • Ball, Vanessa
  • Hatton, Paulette
  • Dall'Antonia, Martino
Type
Published Article
Journal
Journal of Antimicrobial Chemotherapy
Publisher
Oxford University Press
Publication Date
Jan 01, 2009
Volume
63
Issue
1
Pages
151–154
Identifiers
DOI: 10.1093/jac/dkn457
PMID: 19001449
Source
Medline
License
Unknown

Abstract

MICs and MBCs of allicin liquid were 35 to 95 mg/L and 75 to 315 mg/L, respectively. Time/dose kill curves produced a 2-3 log reduction in cfu/mL within 3 h and no detectable growth at 8 and 24 h. A novel 500 mg/L allicin gel produced an average zone size of 23+/-6 mm compared with 21+/-6 mm for allicin in water. Aqueous allicin is bactericidal against GBS isolates and maintains activity in a novel gel formulation.

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