Affordable Access

[In vitro activity of 16 antimicrobial agents against Helicobacter (Campylobacter) pylori].

Authors
  • García-Rodríguez, J A
  • García-García, M I
  • García-Sánchez, E
  • García-Sánchez, J E
  • Muñoz Bellido, J L
Type
Published Article
Journal
Enfermedades infecciosas y microbiología clínica
Publication Date
Dec 01, 1989
Volume
7
Issue
10
Pages
544–546
Identifiers
PMID: 2490433
Source
Medline
License
Unknown

Abstract

Campylobacter pylori has been associated with the etiology of gastritis and duodenal ulcer. It has been shown that several drugs, among them a variety of antimicrobials, eliminate C. pylori from gastric mucosa at least for a time, resulting in an improvement of the patients' symptoms. The activity of 16 antimicrobials (ampicillin, cefazolin, cefuroxime, cefotaxime, imipenem, aztreonam, tigemonam, erythromycin, vancomycin, nalidixic acid, colistin , norfloxacin, ciprofloxacin, difloxacin, ofloxacin and perfloxacin) was tested against 30 clinical isolates of C. pylori. The antimicrobials showing the highest activity were ampicillin, imipenem and ciprofloxacin, followed by cefazolin, cefuroxime, cefotaxime, aztreonam, tigemonam, erythromycin and difloxacin. Nalidixic acid, colistin and vancomycin were virtually ineffective against C. pylori.

Report this publication

Statistics

Seen <100 times