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Vitamin-D deficiency impairs CD4+T-cell count recovery rate in HIV-positive adults on highly active antiretroviral therapy: A longitudinal study.

Authors
  • Ezeamama, Amara Esther1
  • Guwatudde, David2
  • Wang, Molin3
  • Bagenda, Danstan4
  • Kyeyune, Rachel5
  • Sudfeld, Christopher6
  • Manabe, Yukari C7
  • Fawzi, Wafaie W8
  • 1 Department of Epidemiology & Biostatistics, The University of Georgia, B.S. Miller Hall Room 125, 101 Buck Rd, Athens, GA, USA. Electronic address: [email protected] , (Georgia)
  • 2 School of Public Health, and Makerere University College of Health Sciences, Kampala, Uganda. , (Uganda)
  • 3 Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
  • 4 School of Public Health, and Makerere University College of Health Sciences, Kampala, Uganda; Department of Global Health and Population, Harvard School of Public Health, Boston, MA, USA. , (Uganda)
  • 5 Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda. , (Uganda)
  • 6 Department of Global Health and Population, Harvard School of Public Health, Boston, MA, USA.
  • 7 Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda; Division of Infectious Diseases, Department of Medicine, John Hopkins University, Baltimore, MD, USA. , (Uganda)
  • 8 Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA; Department of Global Health and Population, Harvard School of Public Health, Boston, MA, USA; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.
Type
Published Article
Journal
Clinical nutrition (Edinburgh, Scotland)
Publication Date
Oct 01, 2016
Volume
35
Issue
5
Pages
1110–1117
Identifiers
DOI: 10.1016/j.clnu.2015.08.007
PMID: 26371397
Source
Medline
Keywords
License
Unknown

Abstract

VDD is associated with lower absolute CD4+T-cell count recovery in HIV-positive patients on HAART. Vitamin-D supplementation may improve CD4+T-cell recovery during HAART. However, future intervention studies are needed to definitively evaluate the effectiveness of this vitamin as an adjunct therapy during HAART.

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