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Vitamin A supplementation and genital shedding of herpes simplex virus among HIV-1-infected women: a randomized clinical trial.

Authors
  • Baeten, Jared M
  • McClelland, R Scott
  • Corey, Lawrence
  • Overbaugh, Julie
  • Lavreys, Ludo
  • Richardson, Barbra A
  • Wald, Anna
  • Mandaliya, Kishorchandra
  • Bwayo, Job J
  • Kreiss, Joan K
Type
Published Article
Journal
The Journal of infectious diseases
Publication Date
Apr 15, 2004
Volume
189
Issue
8
Pages
1466–1471
Identifiers
PMID: 15073684
Source
Medline
License
Unknown

Abstract

Cross-sectional analyses have associated vitamin A deficiency with genital shedding of herpes simplex virus (HSV) among human immunodeficiency virus type 1 (HIV-1)-infected women. A randomized clinical trial of vitamin A supplementation given daily for 6 weeks was conducted among 376 women in Mombasa, Kenya, who were coinfected with HSV-2 and HIV-1. At follow-up, there was no significant difference in the detection of genital HSV DNA between women receiving vitamin A supplementation and women receiving placebo (40% vs. 44%, respectively; P = .5) Among women shedding HSV, there was no significant difference in the mean HSV DNA quantity between the group that received vitamin A supplementation and the group that received placebo (4.51 vs. 4.67 log10 copies/swab; P = .6). HSV shedding was associated with significantly higher vaginal and cervical HIV-1 shedding, even after controlling for the plasma HIV-1 load and the CD4 count. Vitamin A supplementation is unlikely to decrease HSV shedding and infectivity.

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