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Vitamin D3: a helpful immuno-modulator.

Authors
  • Di Rosa, Michelino
  • Malaguarnera, Michele
  • Nicoletti, Ferdinando
  • Malaguarnera, Lucia
Type
Published Article
Journal
Immunology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Oct 01, 2011
Volume
134
Issue
2
Pages
123–139
Identifiers
DOI: 10.1111/j.1365-2567.2011.03482.x
PMID: 21896008
Source
Medline
License
Unknown

Abstract

The active metabolite of vitamin D, 1α, 25-dihydroxyvitamin D3 [1,25(OH)(2) D3], is involved in calcium and phosphate metabolism and exerts a large number of biological effects. Vitamin D3 inhibits parathyroid hormone secretion, adaptive immunity and cell proliferation, and at the same time promotes insulin secretion, innate immunity and stimulates cellular differentiation. The role of vitamin D3 in immunoregulation has led to the concept of a dual function as both as an important secosteroid hormone for the regulation of body calcium homeostasis and as an essential organic compound that has been shown to have a crucial effect on the immune responses. Altered levels of vitamin D3 have been associated, by recent observational studies, with a higher susceptibility of immune-mediated disorders and inflammatory diseases. This review reports the new developments with specific reference to the metabolic and signalling mechanisms associated with the complex immune-regulatory effects of vitamin D3 on immune cells.

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