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Vitamin D Receptor Gene Polymorphisms Are Associated With Leprosy in Southern Brazil

Authors
  • Pepineli, Afonso Carrasco1
  • Alves, Hugo Vicentin1
  • Tiyo, Bruna Tiaki1
  • Macedo, Luciana Conci1
  • Visentainer, Lorena2
  • de Lima Neto, Quirino Alves1
  • Zacarias, Joana Maira Valentini1
  • Sell, Ana Maria1
  • Visentainer, Jeane Eliete Laguila1
  • 1 Laboratory of Immunogenetics, Department of Basic Health Sciences, Maringá State University (UEM), Maringá , (Brazil)
  • 2 Department of Medicine, Faculty of Medical Sciences, Campinas State University (UNICAMP), São Paulo , (Brazil)
Type
Published Article
Journal
Frontiers in Immunology
Publisher
Frontiers Media SA
Publication Date
Oct 04, 2019
Volume
10
Identifiers
DOI: 10.3389/fimmu.2019.02157
PMID: 31636627
PMCID: PMC6787522
Source
PubMed Central
Keywords
License
Unknown

Abstract

Vitamin D, together with its nuclear receptor (VDR), plays an important role in modulating the immune response, decreasing the inflammatory process. Some polymorphisms of the VDR gene, such as Bsm I (G>A rs1544410) , Apa I (G>T rs7975232), and Taq I (T>C rs731236) could affect its stability and mRNA transcription activity, while Fok I T>C (rs2228570) gives a truncated protein with three fewer amino acids and more efficiency in binding vitamin D. This study evaluated these four polymorphisms in the immunopathogenesis of leprosy in 404 patients and 432 control individuals without chronic or infectious disease in southern Brazil. When analyzing differences in the allele and genotype frequency of polymorphisms between patients (leprosy per se , multibacillary, and paucibacillary clinical forms) and controls, we found no statistically significant association. Regarding haplotype analysis, the bAt haplotype was associated with protection from leprosy per se ( P = 0.004, OR = 0.34, CI = 0.16–0.71) and from the multibacillary clinical form ( P = 0.005, OR = 0.30, CI = 0.13–0.70). In individuals aged 40 or more years, this haplotype has also showed protection against leprosy per se and multibacillary (OR = 0.26, CI = 0.09–0.76; OR = 0.26, CI = 0.07–0.78, respectively), while the BAt haplotype was a risk factor for leprosy per se in the same age group (OR = 1.34, CI = 1.04–1.73). In conclusion, despite having found no associations between the VDR gene polymorphisms with the development of leprosy, the haplotypes formed by the Bsm I, Apa I, and Taq I polymorphisms were associated with leprosy per se and the multibacillary clinical form.

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