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Vitamin B-6 restriction tends to reduce the red blood cell glutathione synthesis rate without affecting red blood cell or plasma glutathione concentrations in healthy men and women.

Authors
  • Lamers, Yvonne
  • O'Rourke, Bruce
  • Gilbert, Lesa R
  • Keeling, Christine
  • Matthews, Dwight E
  • Stacpoole, Peter W
  • Gregory, Jesse F 3rd
Type
Published Article
Journal
American Journal of Clinical Nutrition
Publisher
Oxford University Press
Publication Date
Aug 01, 2009
Volume
90
Issue
2
Pages
336–343
Identifiers
DOI: 10.3945/ajcn.2009.27747
PMID: 19515736
Source
Medline
License
Unknown

Abstract

Marginal vitamin B-6 deficiency tended to decrease mean RBC glutathione synthesis with no effect on RBC glutathione concentration, but the responses varied widely among individuals. Because the cysteine concentration in plasma and RBC did not change during vitamin B-6 restriction, we conclude that the effects of marginal vitamin B-6 deficiency on glutathione synthesis are not caused by altered precursor concentrations.

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