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Visual System Involvement in Patients with Newly Diagnosed Parkinson Disease.

Authors
  • Arrigo, Alessandro1
  • Calamuneri, Alessandro1
  • Milardi, Demetrio1
  • Mormina, Enricomaria1
  • Rania, Laura1
  • Postorino, Elisa1
  • Marino, Silvia1
  • Di Lorenzo, Giuseppe1
  • Anastasi, Giuseppe Pio1
  • Ghilardi, Maria Felice1
  • Aragona, Pasquale1
  • Quartarone, Angelo1
  • Gaeta, Michele1
  • 1 From the Department of Opthalmology, IRCCS Ospedale San Raffaele, University Vita-Salute, via Olgettina 60, Milan, 20132, Italy (A.A.); Department of Biomedical Science and Morphological and Functional Images, University of Messina, Azienda Ospedaliera Universitaria Policlinico G. Martino, Messina, Italy (A.A., A.C., D.M., E.M., L.R., E.P., G.P.A., P.A., A.Q., M.G.); IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy (D.M., S.M., G.D.L.); and Sophie Davis School for Biomedical Education at CCNY, City University of New York, New York, NY (M.F.G.). , (Italy)
Type
Published Article
Journal
Radiology
Publisher
Radiological Society of North America
Publication Date
Dec 01, 2017
Volume
285
Issue
3
Pages
885–895
Identifiers
DOI: 10.1148/radiol.2017161732
PMID: 28696183
Source
Medline
License
Unknown

Abstract

Purpose To assess intracranial visual system changes of newly diagnosed Parkinson disease in drug-naïve patients. Materials and Methods Twenty patients with newly diagnosed Parkinson disease and 20 age-matched control subjects were recruited. Magnetic resonance (MR) imaging (T1-weighted and diffusion-weighted imaging) was performed with a 3-T MR imager. White matter changes were assessed by exploring a white matter diffusion profile by means of diffusion-tensor imaging-based parameters and constrained spherical deconvolution-based connectivity analysis and by means of white matter voxel-based morphometry (VBM). Alterations in occipital gray matter were investigated by means of gray matter VBM. Morphologic analysis of the optic chiasm was based on manual measurement of regions of interest. Statistical testing included analysis of variance, t tests, and permutation tests. Results In the patients with Parkinson disease, significant alterations were found in optic radiation connectivity distribution, with decreased lateral geniculate nucleus V2 density (F, -8.28; P < .05), a significant increase in optic radiation mean diffusivity (F, 7.5; P = .014), and a significant reduction in white matter concentration. VBM analysis also showed a significant reduction in visual cortical volumes (P < .05). Moreover, the chiasmatic area and volume were significantly reduced (P < .05). Conclusion The findings show that visual system alterations can be detected in early stages of Parkinson disease and that the entire intracranial visual system can be involved. © RSNA, 2017 Online supplemental material is available for this article.

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