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[Visceral leishmaniasis associated hemophagocytic lymphohistiocytosis: report of four childhood cases].

Authors
  • Guo, Xia
  • Chen, Na
  • Wang, Tian-you
  • Zhou, Chen-yan
  • Li, Qiang
  • Gao, Ju
Type
Published Article
Journal
Zhonghua er ke za zhi. Chinese journal of pediatrics
Publication Date
Jul 01, 2011
Volume
49
Issue
7
Pages
550–553
Identifiers
PMID: 22088188
Source
Medline
License
Unknown

Abstract

VL, a parasitic disease caused by Leishmania donovani, which is currently endemic just in 6 provinces in China, shares similar clinical picture of HLH and is an easily ignored underlying cause of secondary HLH. We suggest that VL should be in the list of differential diagnosis for any patients with HLH who lives in or has a definite travel history to endemic areas. Repeated bone marrow studies are highly warranted to make a definite diagnosis of VL, because bone marrow aspirate or rk39 dipstick test during early disease course might yield negative results. Although VL-HLH responds quite well to HLH-tailored chemotherapy, specific therapy against VL must be given to prevent disease recurrence, and HLH-targeted chemotherapy might be discontinued to prevent chemotherapy-related toxicities.

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