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Virus signaling and apoptosis in the central nervous system infection.

Authors
  • Perkins, Dana
Type
Published Article
Journal
Frontiers in Bioscience
Publisher
Frontiers in BioScience
Publication Date
Jan 01, 2005
Volume
10
Pages
2804–2819
Identifiers
PMID: 15970535
Source
Medline
License
Unknown

Abstract

Viruses target the central nervous system (CNS) incidentally, due to complications of systemic infection, or specifically, by ascending via the axons of peripheral and cranial nerves. In the CNS, viruses cause acute disease (viz. encephalitis), latent infections or neurodegenerative pathology. Causation of acute disease or immune-mediated pathology, and virus involvement in the etiology of chronic neurodegenerative diseases depends, at least in part, on the ability to commander signaling pathways. Better understanding of these virus-host cell interactions will help identify molecular targets for the development of improved therapeutic strategies.

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