Affordable Access

deepdyve-link
Publisher Website

Virtual magnetic resonance elastography has the feasibility to evaluate preoperative pituitary adenoma consistency.

Authors
  • Lagerstrand, Kerstin1, 2
  • Gaedes, Nicholas3
  • Eriksson, Stig4
  • Farahmand, Dan5, 6
  • De Coursey, Erica4
  • Johansson, Gudmundur7, 8
  • Jönsson, Lars4
  • Skoglund, Thomas5, 6
  • 1 Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, Göteborg, Sweden. [email protected] , (Sweden)
  • 2 Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden. [email protected] , (Sweden)
  • 3 Philips, Göteborg, Sweden. , (Sweden)
  • 4 Department of Radiology, Sahlgrenska University Hospital, Göteborg, Sweden. , (Sweden)
  • 5 Department of Neurosurgery, Sahlgrenska University Hospital, Göteborg, Sweden. , (Sweden)
  • 6 Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden. , (Sweden)
  • 7 Department of Medicine, Sahlgrenska University Hospital, Göteborg, Sweden. , (Sweden)
  • 8 Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden. , (Sweden)
Type
Published Article
Journal
Pituitary
Publisher
Springer-Verlag
Publication Date
Feb 08, 2021
Identifiers
DOI: 10.1007/s11102-021-01129-4
PMID: 33555485
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To evaluate the use of preoperative virtual Magnetic Resonance Elastography (vMRE) for patients undergoing transsphenoidal resection of pituitary adenomas (PA). Ten patients (60.2 ± 19.6 years; 8 males) were prospectively examined with the vMRE-method prior to transsphenoidal surgery. vMRE-images, reflecting tissue stiffness were reconstructed. From these images, histograms as well as the mean stiffness values over the tumor body were extracted. Finally, vMRE-data was compared with the PA consistency at surgery blinded to vMRE. In all patients, successful vMRE-examination was performed enabling evaluation of even small PAs. For tumors with homogenous tissue, the mean stiffness value increased with surgical consistency grading. For heterogenous tumors, however, the mean stiffness value did not consistently reflect the grading at surgery. On the other hand, the vMRE-images and histograms were found to be able to characterize the tumor heterogeneity and display focal regions of high stiffness that were found to affect the surgery outcome in these PAs. The vMRE-images and histograms showed great promise in characterizing the consistency at surgery for these PAs. Evaluation of PA consistency in preparation for surgery seems to be feasible using the vMRE-method. Our findings also address the need for high resolution diagnostic methods that can non-invasively display focal regions of increased stiffness, as such regions may increase the difficulty of transsphenoidal PA-resection.

Report this publication

Statistics

Seen <100 times