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Viremia preceding multiple sclerosis: Two nested case-control studies.

Authors
  • Hultin, Emilie1
  • Mühr, Laila Sara Arroyo1
  • Bzhalava, Zurab1
  • Hortlund, Maria1
  • Lagheden, Camilla1
  • Sundström, Peter2
  • Dillner, Joakim3
  • 1 Department of Laboratory Medicine, Karolinska Institutet, Huddinge SE-141 86, Sweden. , (Sweden)
  • 2 Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå SE-901 87, Sweden. , (Sweden)
  • 3 Department of Laboratory Medicine, Karolinska Institutet, Huddinge SE-141 86, Sweden. Electronic address: [email protected] , (Sweden)
Type
Published Article
Journal
Virology
Publisher
Elsevier
Publication Date
May 14, 2018
Volume
520
Pages
21–29
Identifiers
DOI: 10.1016/j.virol.2018.04.006
PMID: 29772404
Source
Medline
Keywords
License
Unknown

Abstract

Infections have been suggested to be involved in Multiple Sclerosis (MS). We used metagenomic sequencing to detect both known and yet unknown microorganisms in 2 nested case control studies of MS. Two different cohorts were followed for MS using registry linkages. Serum samples taken before diagnosis as well as samples from matched control subjects were selected. In cohort1 with 75 cases and 75 controls, most viral reads were Anelloviridae-related and >95% detected among the cases. Among samples taken up to 2 years before MS diagnosis, Anellovirus species TTMV1, TTMV6 and TTV27 were significantly more common among cases. In cohort2, 93 cases and 93 controls were tested under the pre-specified hypothesis that the same association would be found. Although most viral reads were again related to Anelloviridae, no significant case-control differences were seen. We conclude that the Anelloviridae-MS association may be due to multiple hypothesis testing, but other explanations are possible.

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