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Viral stimuli trigger exaggerated thymic stromal lymphopoietin expression by chronic obstructive pulmonary disease epithelium: role of endosomal TLR3 and cytosolic RIG-I-like helicases.

Authors
  • Calvén, Jenny
  • Yudina, Yulyana
  • Hallgren, Oskar
  • Westergren-Thorsson, Gunilla
  • Davies, Donna E
  • Brandelius, Angelica
  • Uller, Lena
Type
Published Article
Journal
Journal of Innate Immunity
Publisher
S. Karger AG
Publication Date
Jan 01, 2012
Volume
4
Issue
1
Pages
86–99
Identifiers
DOI: 10.1159/000329131
PMID: 21691053
Source
Medline
License
Unknown

Abstract

Endosomal TLR3-stimulation, by dsRNA or RV16, induces overproduction of TSLP in COPD-BEC. dsRNA- and RV-induced overproduction of TNF-α and CXCL8 involves endosomal TLR3 and cytosolic RIG-I-like helicases and so does the generation of IFN-β in COPD-BEC. RV16 and dsRNA-induced epithelial TSLP may contribute to pathogenic effects at exacerbations and development of COPD.

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