Affordable Access

Viral-mediated FGF-2 treatment of the constant light damage model of photoreceptor degeneration.

Authors
  • Lau, Dana
  • Flannery, John
Type
Published Article
Journal
Documenta ophthalmologica. Advances in ophthalmology
Publication Date
Jan 01, 2003
Volume
106
Issue
1
Pages
89–98
Identifiers
PMID: 12675490
Source
Medline
License
Unknown

Abstract

These experiments evaluate overexpression of basic fibroblast growth factor (FGF-2) as a treatment to decrease photoreceptor cell death in the constant light damage model of retinal degeneration. Increased FGF-2 expression was accomplished by gene transfer to the retina via injection into the subretinal space of a recombinant adeno-associated virus (rAAV), containing the FGF-2 gene. Rescue effects were assessed by morphometry and electroretinographic analysis.

Report this publication

Statistics

Seen <100 times