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Viral measurement by polymerase chain reaction-based assays in human immunodeficiency virus-infected infants.

Authors
  • Palumbo, P E
  • Kwok, S
  • Waters, S
  • Wesley, Y
  • Lewis, D
  • McKinney, N
  • Bardeguez, A
  • Connor, E M
  • Oleske, J M
Type
Published Article
Journal
The Journal of Pediatrics
Publisher
Elsevier
Publication Date
Apr 01, 1995
Volume
126
Issue
4
Pages
592–595
Identifiers
PMID: 7699539
Source
Medline
License
Unknown

Abstract

Serial samples from human immunodeficiency virus-infected infants in the first year of life were analyzed by quantitative human immunodeficiency virus polymerase chain reaction assays. Very high, persistent levels of plasma RNA and proviral DNA were detected throughout the study period, suggesting the absence of an effective immune response. Most patients had normal CD4 lymphocyte counts and were symptom free for the first 3 to 6 months despite high levels of viral replication. These findings support the evaluation of early intervention (before symptoms develop) and efforts to establish the predictive value of these assays.

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