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Viral apoptotic mimicry.

Authors
Type
Published Article
Journal
Nature Reviews Microbiology
Publisher
Springer Nature
Publication Date
Aug 16, 2015
Volume
13
Issue
8
Pages
461–469
Identifiers
DOI: 10.1038/nrmicro3469
PMID: 26052667
Source
USPC - SET - SVS
License
Green

Abstract

As opportunistic pathogens, viruses have evolved many elegant strategies to manipulate host cells for infectious entry and replication. Viral apoptotic mimicry, defined by the exposure of phosphatidylserine - a marker for apoptosis - on the pathogen surface, is emerging as a common theme used by enveloped viruses to promote infection. Focusing on the four best described examples (vaccinia virus, dengue virus, Ebola virus and pseudotyped lentivirus), we summarize our current understanding of apoptotic mimicry as a mechanism for virus entry, binding and immune evasion. We also describe recent examples of non-enveloped viruses that use this mimicry strategy, and discuss future directions and how viral apoptotic mimicry could be targeted therapeutically.

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