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VIP modulation of cultured glial cells of the rat retina.

Authors
  • Koh, S W
  • Roberge, F G
Type
Published Article
Journal
Current eye research
Publication Date
Nov 01, 1989
Volume
8
Issue
11
Pages
1207–1210
Identifiers
PMID: 2558850
Source
Medline
License
Unknown

Abstract

Cultured retinal glial cells from the rat are responsive to modulation by vasoactive intestinal peptide (VIP). VIP (1 X 10(-6) M) elevated the intracellular cyclic AMP concentration from the basal level of (4.4-11.1) p mole/mg protein to (354-440) p mole/mg protein in three minutes at 25 degrees C. The half-maximal concentration is 4.8 X 10(-8) M, which is similar to that observed in the cultured retinal glial cells from the chick embryo.

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