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Vincristine and sirolimus in the treatment of kaposiform haemangioendothelioma.

Authors
  • Peng, Suhua1
  • Yang, Kaiying1
  • Xu, Zhicheng1
  • Chen, Siyuan2
  • Ji, Yi1
  • 1 Division of Oncology, Department of Paediatric Surgery, West China Hospital of Sichuan University, Chengdu, China. , (China)
  • 2 Paediatric Intensive Care Unit, Department of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, China. , (China)
Type
Published Article
Journal
Journal of Paediatrics and Child Health
Publisher
Wiley (Blackwell Publishing)
Publication Date
Sep 01, 2019
Volume
55
Issue
9
Pages
1119–1124
Identifiers
DOI: 10.1111/jpc.14370
PMID: 30604513
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Kaposiform haemangioendothelioma (KHE) is a rare, potentially life-threatening vascular tumour that is often associated with thrombocytopenia and coagulopathy, known as the Kasabach-Merritt phenomenon (KMP). Because of the rarity and complexity of KHE, the optimal paradigm for treating KHE has yet to be elucidated. We aim to assess the efficacy and safety of vincristine and sirolimus for the treatment of KHE. A comprehensive review of the literature was conducted from January 1993 to June 2018. A total of 15 studies were selected for the meta-analysis. Five studies included 75 individuals and reported the response and side effects to vincristine in the treatment of KHE with or without KMP. A total of 10 studies that included 127 individuals reported the response and safety of sirolimus for treating KHE with or without KMP. The pooled odds ratio (OR) for the effectiveness of vincristine was 0.72. The pooled OR for the effectiveness of sirolimus was 0.91. The side effects associated with vincristine during the treatment included neuropathy, abdominal pain, loss of appetite and mild elevations of aspartate aminotransferase (AST) and alanine aminotransferase (ALT). The side effects associated with sirolimus therapy included bronchitis; lymphopenia; elevated AST, ALT and platelets; hyperlipidaemia; opportunistic infection; mild reversible leukopenia; mucositis; fever; pain and skin rash/vomiting and diarrhoea. This systematic review showed a high efficacy of vincristine and sirolimus in the treatment of KHE. Based on the available data in the literature, it appears that sirolimus is potentially an efficacious and safe treatment option for KHE. Further randomised, controlled trials are recommended. © 2019 Paediatrics and Child Health Division (The Royal Australasian College of Physicians).

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