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Vinblastine, a chemotherapeutic drug, inhibits palmitoylation of tubulin in human leukemic lymphocytes.

Authors
  • Caron, Joan M1
  • Herwood, Margot
  • 1 Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA. [email protected]
Type
Published Article
Journal
Chemotherapy
Publication Date
2007
Volume
53
Issue
1
Pages
51–58
Identifiers
PMID: 17202812
Source
Medline
License
Unknown

Abstract

This study identifies a previously unknown mechanism of action of vinblastine, the depalmitoylation of tubulin, and suggests that depalmitoylation of tubulin may be a target for new chemotherapeutic drugs.

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