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Increased SGLT1 expression in salivary gland ductal cells correlates with hyposalivation in diabetic and hypertensive rats

  • Sabino-Silva, Robinson1, 2, 3
  • Okamoto, Maristela Mitiko2
  • David-Silva, Aline2
  • Mori, Rosana Cristina2
  • Freitas, Helayne Soares2
  • Machado, Ubiratan Fabres2
  • 1 Universidade Federal de Uberlândia, Instituto de Ciências Biomédicas, Área de Fisiologia e Farmacologia Av. Pará, 1720 Campus Umuruama, Uberlândia, MG, CEP: 38400-902, Brazil , Uberlândia (Brazil)
  • 2 University of Sao Paulo, Department of Physiology and Biophysics, Institute of Biomedical Sciences, Sao Paulo, Brazil , Sao Paulo (Brazil)
  • 3 Federal University of Alagoas (UFAL), Cidade Universitária, Institute of Biological Sciences and Health, Av. Lourival de Melo Mota, km 14, Campus A. C. Simões, Maceió, AL, CEP 57072-970, Brazil , Maceió (Brazil)
Published Article
Diabetology & Metabolic Syndrome
BioMed Central
Publication Date
Oct 24, 2013
DOI: 10.1186/1758-5996-5-64
Springer Nature


BackgroundOral health complications in diabetes and hypertension include decreased salivary secretion. The sodium-glucose cotransporter 1 (SGLT1) protein, which transports 1 glucose/2 Na+/264 H2O molecules, is described in salivary glands. We hypothesized that changes in SGLT1 expression in the luminal membrane of ductal cell may be related to an altered salivary flow.FindingsBy immunohistochemistry, we investigated SGLT1 expression in ductal cells of parotid and submandibular glands from Wistar Kyoto rats (WKY), diabetic WKY (WKY-D), spontaneously hypertensive rats (SHR) and diabetic SHR (SHR-D), as well as in parotid glands from WKY subjected to sympathetic stimulation, with or without previous propranolol blockade. Diabetes and hypertension decreased the salivary secretion and increased SGLT1 expression in the luminal membrane of ductal cells, and their association exacerbated the regulations observed. After 30 min of sympathetic stimulation, SGLT1 increased in the luminal membrane of ductal cells, and that was blocked by previous injection of propranolol.ConclusionsSGLT1 expression increases in the luminal membrane of salivary gland ductal cells and the salivary flow decreases in diabetic and hypertensive rats, which may be related to sympathetic activity. This study highlights the water transporter role of SGLT1 in salivary glands, which, by increasing ductal water reabsorption, may explain the hyposalivation of diabetic and hypertensive subjects.

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