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Verucopeptin, a new antitumor antibiotic active against B16 melanoma. I. Taxonomy, production, isolation, physico-chemical properties and biological activity.

Authors
  • Nishiyama, Y
  • Sugawara, K
  • Tomita, K
  • Yamamoto, H
  • Kamei, H
  • Oki, T
Type
Published Article
Journal
The Journal of antibiotics
Publication Date
Jun 01, 1993
Volume
46
Issue
6
Pages
921–927
Identifiers
PMID: 8344873
Source
Medline
License
Unknown

Abstract

A new antitumor antibiotic verucopeptin was isolated from the culture broth of Actinomadura verrucosospora Q886-2. It should potent cytotoxicity and specific in vivo activity against B16 melanoma. Maximum T/C value (162%) was obtained by Q1D x 1 treatment schedule.

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