Affordable Access

Publisher Website

Creation of Chemically Tri-Layered Collagen Crosslinked Membranes and Their Comparison with Ionically Tri-Layered Chitosan Crosslinked Membranes to Study Human Skin Properties.

Authors
  • Galán-Navea, Larry1
  • Guerle-Cavero, Rocío1
  • Balfagón-Costa, Albert1
  • Artalejo-Ortega, Beatriz1
  • 1 Pharmaceutical Chemistry Research Group, Institut Químic de Sarrià, Universitat Ramón Llull, 08017 Barcelona, Spain. , (Spain)
Type
Published Article
Journal
International Journal of Molecular Sciences
Publisher
MDPI AG
Publication Date
Aug 30, 2023
Volume
24
Issue
17
Identifiers
DOI: 10.3390/ijms241713443
PMID: 37686251
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

In 2009, a new European regulation came into force that forbade the use of animals in the cosmetics industry. As a result, new alternatives were sought, taking into account the new ethical considerations. The main objective of this article is to continue a line of research that aims to build a physical model of skin from a biomaterial scaffold composed of collagen, chitosan or a combination to investigate whether they offer similar behavior to human skin. Collagen, the major component in the dermis, was crosslinked with glutaraldehyde (GTA) to develop three formulations for studying some properties of the skin through rheological tests like swelling index, elasticity or water loss. In addition, this article makes a comparison with the results obtained in the previous article where the membranes were made of chitosan and tripolyphosphate (TPP). The results obtained highlight that the tri-layered membranes scaffold better than the mono-layered ones to increase the elastic modulus (G') and the permeability. Furthermore, they offer a protective effect against water loss compared to mono-layered membranes. As regards chitosan membranes, these have a higher G' modulus than collagen membranes when the degree of deacetylation (DDA) is 85%. However, collagen membranes are more elastic when the DDA of chitosan is 76%, and their linear viscoelastic limit (LVL) doubles that of chitosan membranes, both for the degree of acetylation of 76 and 85%.

Report this publication

Statistics

Seen <100 times