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A versatile and practical microwave-assisted synthesis of sterically hindered N-arylpiperazines.

Authors
  • Gao, Rong
  • Canney, Daniel J
Type
Published Article
Journal
The Journal of Organic Chemistry
Publisher
American Chemical Society
Publication Date
Nov 05, 2010
Volume
75
Issue
21
Pages
7451–7453
Identifiers
DOI: 10.1021/jo101478c
PMID: 20863109
Source
Medline
License
Unknown

Abstract

A wide-ranging and practical synthesis of structurally diverse, sterically hindered N-arylpiperazines from 2,2'-(4-nitrophenylsulfonylazanediyl) bis(ethane-2,1-diyl) bis(4-nitrobenzenesulfonate) and substituted anilines has been achieved using microwave irradiation in acetonitrile followed by deprotection with PhSH.

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