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A versatile cathodic "signal-on" photoelectrochemical platform based on a dual-signal amplification strategy.

Authors
  • Li, Ying1
  • Chen, Fengting1
  • Luan, Zhenzhu2
  • Zhang, Xiaoru3
  • 1 Key Laboratory of Sensor Analysis of Tumor Marker, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Scienceand Technology, Qingdao 266042, PR China. , (China)
  • 2 Shandong Key Laboratory of Biochemical Analysis, College of Chemistry and Molecular Engineering, Qingdao University of Scienceand Technology, Qingdao 266042, PR China. , (China)
  • 3 Shandong Key Laboratory of Biochemical Analysis, College of Chemistry and Molecular Engineering, Qingdao University of Scienceand Technology, Qingdao 266042, PR China; Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong, College of Chemistry and Molecular Engineering, Qingdao University of Scienceand Technology, Qingdao 266042, PR China.. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Biosensors & bioelectronics
Publication Date
Nov 15, 2018
Volume
119
Pages
63–69
Identifiers
DOI: 10.1016/j.bios.2018.07.068
PMID: 30099233
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Novel cathodic photoelectrochemical (PEC) aptasensors for sensitive and selective determination of thrombin and Pb2+ were developed based on a new dual-signal amplification strategy. The presence of gold nanoparticles (AuNPs) could quench the PEC signal of bismuth oxyiodide (BiOI). At the same time, the redox moiety G-quadruplex/hemin or ferrocene (Fc) was found to enhance the PEC signal of BiOI. So, in the presence of thrombin or Pb2+, the interaction between target and the aptamer resulted in the releasement of the AuNPs, as well as shorter distance between the redox moiety and the electrode surface. Hence dual-enhanced cathodic PEC biosensor strategy was realized. Under the optimized conditions, the detection limits of thrombin and Pb2+ were 17.3 fM and 3.16 pM, respectively with good selectivity. At the same time, the PEC performance of redox moiety G-quadruplex/hemin and Fc was compared. Copyright © 2018 Elsevier B.V. All rights reserved.

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