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A versatile, automated and high-throughput drug screening platform for zebrafish embryos

Authors
  • Lubin, Alexandra1
  • Otterstrom, Jason2
  • Hoade, Yvette1
  • Bjedov, Ivana3
  • Stead, Eleanor3
  • Whelan, Matthew4
  • Gestri, Gaia5
  • Paran, Yael2
  • Payne, Elspeth1
  • 1 Cancer Institute, University College London, Research Department of Haematology, London WC1E 6DD
  • 2 IDEA Bio-Medical Ltd., Rehovot 76705 , (Israel)
  • 3 Cancer Institute, University College London, Research Department of Cancer Biology, London WC1E 6DD
  • 4 University College London, Division of Infection and Immunity, London WC1E 6BT
  • 5 University College London, Department of Cell and Developmental Biology, London WC1E 6AR
Type
Published Article
Journal
Biology Open
Publisher
The Company of Biologists
Publication Date
Sep 02, 2021
Volume
10
Issue
9
Identifiers
DOI: 10.1242/bio.058513
PMID: 34472582
PMCID: PMC8430230
Source
PubMed Central
Keywords
Disciplines
  • Methods & Techniques
License
Unknown

Abstract

Summary: We developed and validated a fast, flexible and rapidly customisable platform, automating both image acquisition and quantitative analysis, for high-content drug screening in live zebrafish embryos.

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