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Verification of intramolecular hybrid/parallel g-quadruplex structure under physiological conditions using novel cyanine dye H-aggregates: both in solution and on Au film.

Authors
  • Yang, Qianfan
  • Xiang, Jun-Feng
  • Yang, Shu
  • Li, Qian
  • Zhou, Qiuju
  • Guan, Aijiao
  • Li, Lin
  • Zhang, Yanxia
  • Zhang, Xiufeng
  • Zhang, Hong
  • Tang, Yalin
  • Xu, Guangzhi
Type
Published Article
Journal
Analytical Chemistry
Publisher
American Chemical Society
Publication Date
Nov 15, 2010
Volume
82
Issue
22
Pages
9135–9137
Identifiers
DOI: 10.1021/ac1017716
PMID: 20968302
Source
Medline
License
Unknown

Abstract

The H-aggregates of a novel cyanine dye, 3,3'-di(3-sulfopropyl)-4,5,4',5'-dibenzo-9-methyl-thiacarbocyanine triethylammonium salt (MTC), have been fabricated to verify hybrid/parallel intramolecular G-quadruplexes from linear duplex and single-strand DNAs under physiological conditions. The recognition is found to be successful both in solution and on Au film. These results have shown MTC H-aggregates, as a supramolecular system, may be used as a potential excellent probe for DNA structure, both in vitro and in vivo.

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