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Verapamil causes decreased diaphragm endurance but no decrease of nocturnal O(2) saturation in patients with chronic obstructive pulmonary disease.

Authors
  • Broeders, M E
  • Heijdra, Y F
  • Smits, P
  • Folgering, H T
  • Kramers, C
Type
Published Article
Journal
European journal of clinical pharmacology
Publication Date
Jan 01, 2000
Volume
55
Issue
10
Pages
729–732
Identifiers
PMID: 10663450
Source
Medline
License
Unknown

Abstract

The decrease of the respiratory muscle endurance after the use of verapamil is in line with experiments in animal diaphragms. However, the nocturnal saturation did not change. This finding suggests that the effect found on diaphragm endurance is of no clinical significance and that verapamil can be given to COPD patients without risk of worsening nocturnal saturation. However, this must be confirmed by future larger scale studies.

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