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The VENUSS prognostic model to predict disease recurrence following surgery for non-metastatic papillary renal cell carcinoma: development and evaluation using the ASSURE prospective clinical trial cohort

Authors
  • Klatte, Tobias1, 2, 3
  • Gallagher, Kevin M.4
  • Afferi, Luca5
  • Volpe, Alessandro5
  • Kroeger, Nils6
  • Ribback, Silvia7
  • McNeill, Alan4
  • Riddick, Antony C. P.1
  • Armitage, James N.1
  • ‘Aho, Tevita F.1
  • Eisen, Tim8, 9
  • Fife, Kate8
  • Bex, Axel10
  • Pantuck, Allan J.11
  • Stewart, Grant D.1, 2
  • 1 Addenbrooke’s Hospital, Department of Urology, Cambridge, UK , Cambridge (United Kingdom)
  • 2 University of Cambridge, Department of Surgery, Cambridge, UK , Cambridge (United Kingdom)
  • 3 The Royal Bournemouth and Christchurch Hospitals, Department of Urology, Castle Lane East, Bournemouth, BH7 7DW, UK , Bournemouth (United Kingdom)
  • 4 Western General Hospital, Department of Urology, Edinburgh, UK , Edinburgh (United Kingdom)
  • 5 University of Eastern Piedmont, Division of Urology, Department of Translational Medicine, Novara, Italy , Novara (Italy)
  • 6 Ernst-Moritz-Arndt-University, Department of Urology, Greifswald, Germany , Greifswald (Germany)
  • 7 Ernst-Moritz-Arndt-University, Institute of Pathology, Greifswald, Germany , Greifswald (Germany)
  • 8 Addenbrooke’s Hospital, Department of Oncology, Cambridge, UK , Cambridge (United Kingdom)
  • 9 Astra Zeneca, Cambridge, UK , Cambridge (United Kingdom)
  • 10 The Netherlands Cancer Institute, Division of Surgical Oncology, Department of Urology, Amsterdam, The Netherlands , Amsterdam (Netherlands)
  • 11 University of California-Los Angeles, Institute of Urologic Oncology, Department of Urology, Los Angeles, CA, USA , Los Angeles (United States)
Type
Published Article
Journal
BMC Medicine
Publisher
BioMed Central
Publication Date
Oct 03, 2019
Volume
17
Issue
1
Identifiers
DOI: 10.1186/s12916-019-1419-1
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundThe current World Health Organization classification recognises 12 major subtypes of renal cell carcinoma (RCC). Although these subtypes differ on molecular and clinical levels, they are generally managed as the same disease, simply because they occur in the same organ. Specifically, there is a paucity of tools to risk-stratify patients with papillary RCC (PRCC). The purpose of this study was to develop and evaluate a tool to risk-stratify patients with clinically non-metastatic PRCC following curative surgery.MethodsWe studied clinicopathological variables and outcomes of 556 patients, who underwent full resection of sporadic, unilateral, non-metastatic (T1–4, N0–1, M0) PRCC at five institutions. Based on multivariable Fine-Gray competing risks regression models, we developed a prognostic scoring system to predict disease recurrence. This was further evaluated in the 150 PRCC patients recruited to the ASSURE trial. We compared the discrimination, calibration and decision-curve clinical net benefit against the Tumour, Node, Metastasis (TNM) stage group, University of California Integrated Staging System (UISS) and the 2018 Leibovich prognostic groups.ResultsWe developed the VENUSS score from significant variables on multivariable analysis, which were the presence of VEnous tumour thrombus, NUclear grade, Size, T and N Stage. We created three risk groups based on the VENUSS score, with a 5-year cumulative incidence of recurrence equalling 2.9% in low-risk, 15.4% in intermediate-risk and 54.5% in high-risk patients. 91.7% of low-risk patients had oligometastatic recurrent disease, compared to 16.7% of intermediate-risk and 40.0% of high-risk patients. Discrimination, calibration and clinical net benefit from VENUSS appeared to be superior to UISS, TNM and Leibovich prognostic groups.ConclusionsWe developed and tested a prognostic model for patients with clinically non-metastatic PRCC, which is based on routine pathological variables. This model may be superior to standard models and could be used for tailoring postoperative surveillance and defining inclusion for prospective adjuvant clinical trials.

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