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Ventro-dorsal Hippocampal Pathway Gates Novelty-Induced Contextual Memory Formation

Authors
  • Fredes, Felipe1, 2
  • Silva, Maria Alejandra1
  • Koppensteiner, Peter1
  • Kobayashi, Kenta3
  • Joesch, Maximilian1
  • Shigemoto, Ryuichi1
  • 1 Institute of Science and Technology Austria, Am Campus 1, 3400 Klosterneuburg, Austria
  • 2 Department of Biomedicine, Aarhus University, Ole Worms Alle 6, Building 1182, 8000 Aarhus C, Denmark
  • 3 Section of Viral Vector Development, National Institute for Physiological Sciences, Myodaiji, Okazaki, Japan
Type
Published Article
Journal
Current Biology
Publisher
Cell Press
Publication Date
Jan 11, 2021
Volume
31
Issue
1
Pages
25–38
Identifiers
DOI: 10.1016/j.cub.2020.09.074
PMID: 33065009
PMCID: PMC7808756
Source
PubMed Central
Keywords
Disciplines
  • Article
License
Unknown

Abstract

Novelty facilitates memory formation. Fredes et al. show that mossy cells in the ventral dentate gyrus detect environmental novelty. This information is conveyed to dorsal dentate granule cells and is necessary for novelty-induced contextual memory formation. Conversely, activating this pathway enhances contextual memory in a familiar environment.

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