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Vasotocin, melatonin and narcolepsy: possible involvement of the pineal gland in its patho-physiological mechanism.

Authors
  • Pavel, S
  • Goldstein, R
  • Petrescu, M
Type
Published Article
Journal
Peptides
Publisher
Elsevier
Publication Date
Jan 01, 1980
Volume
1
Issue
4
Pages
281–284
Identifiers
PMID: 7301633
Source
Medline
License
Unknown

Abstract

Both the pineal nonapeptide hormone arginine vasotocin (AVT) (2.5 micrograms) administered intra-nasally and the pineal indole melatonin (50 mg) administered intravenously to three male narcoleptics (two with auxiliary symptoms and one with sleep attacks only), dramatically increased the amount of REM sleep and decreased REM sleep latency. The duration of the sleep onset REM periods in the two narcoleptics with auxiliary symptoms increased by more than 100 percent after AVT and melatonin administration. In the narcoleptic with sleep attacks only both AVT and melatonin induced REM periods at sleep onset. The hypothesis is advanced that narcolepsy represents an impairment of the melatonin-AVT control in the induction and circadian organization of REM sleep associated with an immaturity of REM triggering centers.

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